Evidence-Based Interventions
for bipolar disorder
Bipolar disorder shifts between poles — and so should its evidence. See what works for each bipolar phase, from mania and mixed states through maintenance to bipolar depression.
Developed by researchers from
One synthesis, read your way
Compare the evidence, rank medications against your own priorities, or dig into the underlying trials.
The evidence matrix
Twelve medications set against efficacy and tolerability, one grid per bipolar phase, each cell graded by the certainty of the evidence.
Open the matrixRank medications
Weight the outcomes that matter to you and this decision — the tool ranks the medications by how well the evidence fits your priorities.
Rank medicationsBrowse the database
Every finding behind the matrix, drawn from meta-analyses of randomised trials, with study design, quality and the trials themselves.
Open the databaseA transparent umbrella review
EBI-BD follows the U-REACH framework: gather every relevant review, appraise its quality, and synthesise the findings into one comparable, phase-aware matrix.
About the U-REACH method- I
Identify
Systematically search the meta-analyses of randomised trials across bipolar disorder interventions.
- II
Appraise
Rate the methodological quality of each review and the certainty of its evidence with GRADE.
- III
Synthesise
Combine the findings by bipolar phase and present them in a transparent, comparable matrix.
Who builds it
EBI-BD pairs clinical expertise in bipolar disorder with a dedicated evidence-synthesis methodology.
U-REACH leaders
